Serum integrated screening for pregnancies where NT measurement is not available or can not be obtained: First-trimester (PAPP-A plus hCG footnotes*) plus second-trimester quad (MSAFP, uncongugated estriol, inhibin A, and hCG footnotes*) screening or.Second-trimester serum analyte screening (see CPB 0464 - Serum and Urine Marker Screening for Fetal Aneuploidy) or.Integrated, sequential, or contingent screening: First-trimester triple test (NT, PAPP-A, and hCG footnotes*) plus second-trimester quadruple test (maternal serum alfa-fetoprotein (MSAFP, unconjugated estriol, inhibin A, and hCG footnotes*) screening or.First-trimester NT measurements results combined with the results of first trimester serum analyte tests that include pregnancy-associated plasma protein A (PAPP-A) plus beta-human chorionic gonadotropin (hCG) footnotes* or.First-trimester nuchal translucency (NT) testing alone (without serum analyte screening) for multiple gestations or. ![]() Aetna considers the following noninvasive screening schemes for fetal aneuploidy medically necessary:
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